Naci, Huseyin

Dr Huseyin Naci  


Position held

Assistant Professor of Health Policy


Experience keywords:

Research design; cardiovascular disease; community pharmacist roles in health system; comparative effectiveness research; economic access to medications; evidence-based medicine; health policy evaluation; health technology assessment; market approval of drugs; network meta-analysis; statins; systematic reviews

Research summary > [Click to expand]

Huseyin’s academic interests include research design, comparative effectiveness research, drug regulation, and health policy evaluation. His methodological research focuses on the strengths and weaknesses of study designs in determining the benefits and harms of health care interventions and policies. He is particularly interested in the application of evidence generated from randomized trials, observational studies, and network meta-analyses to decision-making in health policy and clinical practice. Huseyin’s policy-relevant research focuses on the unintended consequences of health policies; market entry requirements for new health technologies; economic access to medications; and the role of health care professionals in caring for individuals with multiple chronic conditions.

He is also interested in research that has implications for clinical practice: using widely popular cholesterol-lowering statins as a case study, he has recently evaluated the comparative clinical benefits and harms of individual statins for the prevention of coronary heart disease.

Sectors and industries to which research relates:

Healthcare; Policy and Regulatory Bodies

Countries and regions to which research relates:

Cyprus; Turkey; United Kingdom; United States


Turkish [Spoken: Fluent, Written: Fluent]

Media experience:

Has written for mainstream press; Radio; TV

Contact Points

LSE email:



Salanti, Georgia and Nikolakopoulou, Adriani and Sutton, Alex J. and Reichenbach, Stephan and Trelle, Sven and Naci, Huseyin and Egger, Matthias (2018) Planning a future randomized clinical trial based on a network of relevant past trials Trials, 19 (365). ISSN 1745-6215

Wallach, Joshua D. and Ross, Joseph S. and Naci, Huseyin (2018) The US Food and Drug Administration’s expedited approval programs: addressing premarket flexibility with enhanced postmarket evidence generation Clinical Trials, 15 (3). 243-246. ISSN 1740-7745

Wallach, Joshua D. and Ross, Joseph S. and Naci, Huseyin (2018) The US Food and Drug Administration’s expedited approval programs: Evidentiary standards, regulatory trade-offs, and potential improvements Clinical Trials. ISSN 1740-7745


Naci, Huseyin and Mossialos, Elias (2017) Accelerated access to new drugs and technologies BMJ, 359. 1-2. ISSN 1756-1833

Naci, Huseyin and Vardas, Panos and Vahanian, Alec and Kirchhof, Paulus and Bardinet, Isabel and Mossialos, Elias (2017) Training the next generation of cardiovascular leaders in health policy and economics European Heart Journal, 38 (45). 3332-3335. ISSN 0195-668X

Naci, Huseyin (2017) What to do (or not to do) when randomization is not possible Journal of Heart and Lung Transplantation, 36 (11). 1174-1177. ISSN 1053-2498

Wenzl, Martin and Naci, Huseyin and Mossialos, Elias (2017) Health policy in times of austerity—a conceptual framework for evaluating effects of policy on efficiency and equity illustrated with examples from Europe since 2008 Health Policy, 121 (9). 947-954. ISSN 0168-8510

Wenzl, Martin and Naci, Huseyin and Mossialos, Elias (2017) Health policy in times of austerity — a conceptual framework for evaluating effects of policy on efficiency and equity illustrated with examples from Europe since 2008 Health Policy, 121 (9). 947-954. ISSN 0168-8510

Salcher, Maximilian and McGuire, Alistair and Muthurangu, Vivek and Kelm, Marcus and Kuehne, Titus and Naci, Huseyin (2017) Avoidable costs of stenting for aortic coarctation in the United Kingdom: an economic model BMC Health Services Research, 17. 258. ISSN 1472-6963

Davis, Courtney and Naci, Huseyin and Gurpinar, Evrim and Poplavska, Elita and Pinto, Ashlyn and Aggarwal, Ajay (2017) Availability of evidence of benefits on overall survival and quality of life of cancer drugs approved by European Medicines Agency: retrospective cohort study of drug approvals 2009-13 BMJ (359). ISSN 1756-1833

Naci, Huseyin and Wouters, Olivier J. and Gupta, Radhika and Ioannidis, John P. A. (2017) Timing and characteristics of cumulative evidence available on novel therapeutic agents receiving Food and Drug Administration accelerated approval Milbank Quarterly, 95 (2). 261-290. ISSN 0887-378X

Kaier, K. and Reinecke, H. and Naci, Huseyin and Frankenstein, L. and Bode, M. and Vach, W. and Hehn, P. and Zirlik, A. and Zehender, M. and Reinöhl, J. (2017) The impact of post-procedural complications on reimbursement, length of stay and mechanical ventilation among patients undergoing transcatheter aortic valve implantation in Germany European Journal of Health Economics, 19 (2). 223-228. ISSN 1618-7598

Naci, Huseyin and Smalley, Katelyn R. and Kesselheim, Aaron S. (2017) Characteristics of pre-approval and post-approval studies for drugs granted accelerated approval by the US food and drug administration JAMA, 318 (7). 626-636. ISSN 0098-7484


Luyten, Jeroen and Naci, Huseyin and Knapp, Martin (2016) Economic evaluation of mental health interventions: an introduction to cost-utility analysis Evidence-Based Mental Health, 19. 49-53. ISSN 1362-0347

Olczak, Kaya and Salcher, Maximillian and Naci, Huseyin (2016) What works best in congenital heart disease? Comparing two interventions for treatment of Aortic Coarctation LSE Health and Social Care (2 Sep 2016) Blog entry

Naci, Huseyin (2016) Communication of treatment rankings obtained from network meta-­analysis using data visualization Circulation: Cardiovascular Quality and Outcomes, 9 (5). 605-608. ISSN 1941-7705

Dhutia, Harshil and Malhotra, Aneil and Gabus, Vincent and Merghani, Ahmed and Finocchiaro, Gherardo and Millar, Lynne and Narain, Rajay and Papadakis, Michael and Naci, Huseyin and Tome, Maite and Sharma, Sanjay (2016) Cost implications of using different ECG criteria for screening young athletes in the United Kingdom Journal of the American College of Cardiology, 68 (7). 702-711. ISSN 0735-1097

Salcher, Maximilian and Naci, Huseyin and Pender, Sarah and Kuehne, Titus and Kelm, Marcus (2016) Bicuspid aortic valve disease: systematic review and meta-analysis of surgical aortic valve repair Open Heart, 3 (2). 1-9. ISSN 2053-3624

Salcher, Maximilian and Naci, Huseyin and Law, Tyler J. and Kuehne, Titus and Schubert, Stephan and Kelm, Marcus (2016) Balloon dilatation and stenting for aortic coarctation: a systematic review and meta-analysis Circulation: Cardiovascular Interventions. ISSN 1941-7632

Naci, Huseyin and Soumerai, Stephen B. (2016) History bias, study design, and the unfulfilled promise of pay-for-performance policies in health care Preventing Chronic Disease, 13 (160133). 1-7. ISSN 1545-1151


Naci, Huseyin and Ioannidis, John P. A. (2015) Evaluation of wellness determinants and interventions by citizen scientists JAMA, 314 (2). 121. ISSN 0098-7484

Naci, Huseyin and Carter, Alexander W. and Mossialos, Elias (2015) Double failure: the shared accountability of governments and firms for the innovation deficit in the pharmaceutical sector BMJ. ISSN 1756-1833

Naci, Huseyin and Carter, Alexander W. and Mossialos, Elias (2015) Why the drug development pipeline is not delivering better medicines BMJ, 351. ISSN 1756-1833

Naci, Huseyin and Lehman, Richard and Wouters, Olivier J. and Goldacre, Ben and Yudkin, John S (2015) Rethinking the appraisal and approval of drugs for type 2 diabetes BMJ, 351 (h5260). ISSN 1756-1833

Naci, Huseyin and Basu, Sanjay and Yudkin, John S (2015) Preventing cardiovascular events with empagliflozin: at what cost? The Lancet Diabetes and Endocrinology, 3 (12). 931. ISSN 2213-8587

Wouters, Olivier J. and Naci, Huseyin and Samani, Nilesh J (2015) QALYs in cost-effectiveness analysis: an overview for cardiologists Heart, 10 (23). 1868-1873. ISSN 1355-6037

Naci, Huseyin and Spackman, Eldon and Fleurence, Rachael (2015) National approaches to comparative effectiveness research In: Sobolev, Boris, (ed.) Handbook of Health Services Research. Springer reference. Springer-Verlag, Berlin, Germany. ISBN 9781461446569

Naci, Huseyin and Ioannidis, John P. A. (2015) How good is "Evidence" from clinical studies of drug effects and why might such evidence fail in the prediction of clinical utility of drugs Annual Review of Pharmacology and Toxicology, 55. 169-189. ISSN 0362-1642

Naci, Huseyin and Cooper, Jacob and Mossialos, Elias (2015) Timely publication and sharing of trial data: opportunities and challenges for comparative effectiveness research in cardiovascular disease European Heart Journal - Quality of Care and Clinical Outcomes. ISSN 2058-5225

Tervonen, Tommi and Naci, Huseyin and van Valkenhoef, Gert and Ades, Anthony E. and Angelis, Aris and Hillege, Hans L. and Postmus, Douwe (2015) Applying multiple criteria decision analysis to comparative benefit-risk assessment: choosing among statins in primary prevention Medical Decision Making, 35 (7). 859-871. ISSN 0272-989X

Mossialos, Elias and Courtin, Emilie and Naci, Huseyin and Benrimoj, Shalom and Bouvy, Marcel and Farris, Karen and Noyce, Peter and Sketris, Ingrid (2015) From "retailers" to health care providers: transforming the role of community pharmacists in chronic disease management Health Policy, 119 (5). 628-639. ISSN 0168-8510

Chambers, James D. and Naci, Huseyin and Wouters, Olivier J. and Pyo, Junhee and Gunjal, Shalak and Kennedy, Ian R. and Hoey, Mark G. and Winn, Aaron and Neumann, Peter J. (2015) An assessment of the methodological quality of published network meta-analyses: a systematic review PLOS ONE, 10 (4). ISSN 1932-6203

Jackson, N. and Atar, D. and Borentain, M. and Breithardt, G. and van Eickels, M. and Endres, M. and Fraass, U. and Friede, T. and Hannachi, H. and Janmohamed, S. and Kreuzer, J. and Landray, M. and Lautsch, D. and Le Floch, C. and Mol, P. and Naci, H. and Samani, N. J. and Svensson, A. and Thorstensen, C. and Tijssen, J. and Vandzhura, V. and Zalewski, A. and Kirchhof, P. (2015) Improving clinical trials for cardiovascular diseases: a position paper from the Cardiovascular Round Table of the European Society of Cardiology European Heart Journal. ISSN 0195-668X


Naci, Huseyin (2014) Does industry sponsorship bias research findings? Health and Social Care at LSE (21 Oct 2014) Blog entry

Naci, Huseyin and Alexander, George Caleb (2014) Regulators should better leverage effectiveness standards to enhance drug value Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 34 (10). 1005-1011. ISSN 0277-0008

Naci, Huseyin and Soumerai, Stephen B and Ross-Degnan, Dennis and Zhang, Fang and Briesacher, Becky A. and Gurwitz, Jerry H. and Madden, Jeanne M. (2014) Medication affordability gains following Medicare Part D are eroding among elderly with multiple chronic conditions Health Affairs, 33 (8). 1435-1443. ISSN 0278-2715

Naci, Huseyin (2014) Persistent medication affordability problems among disabled medicare beneficiaries after Part D, 2006-2011 Medical Care, 52 (11). 951-956. ISSN 0025-7079

Naci, Huseyin and van Valkenhoef, G. and Higgins, J. P. T. and Fleurence, R. and Ades, A. E. (2014) Evidence-based prescribing: combining network meta-analysis with multicriteria decision analysis to choose among multiple drugs Circulation: Cardiovascular Quality and Outcomes, 7 (5). 787-792. ISSN 1941-7705

Naci, Huseyin and Dias, Sofia and Ades, A. E. (2014) Industry sponsorship bias in research findings: a network meta-analysis of LDL cholesterol reduction in randomised trials of statins BMJ, 349 (oct03). g5741-g5741. ISSN 1756-1833


Naci, Huseyin and O’Connor, Alec B (2013) Assessing comparative effectiveness of new drugs before approval using prospective network meta-analyses Journal of Clinical Epidemiology, 66 (8). 812-816. ISSN 0895-4356

Jansen, Jeroen P. and Naci, Huseyin (2013) Is network meta-analysis as valid as standard pairwise meta-analysis? It all depends on the distribution of effect modifiers BMC Medicine, 11 (1). 159. ISSN 1741-7015

Naci, H. and Ioannidis, J. P. A. (2013) Comparative effectiveness of exercise and drug interventions on mortality outcomes: metaepidemiological study BMC, 347 (oct01). 1-14. ISSN 1756-1833

Naci, Huseyin and Brugts, Jasper Jan and Fleurence, Rachael and Ades, Anthony E. (2013) Comparative effects of statins on major cerebrovascular events: a multiple-treatments meta-analysis of placebo-controlled and active-comparator trials QJM - Monthly Journal of the Association of Physicians, 106 (4). 299-306. ISSN 1460-2725

Naci, Huseyin and Brugts, Jasper Jan and Ades, Tony (2013) Comparative tolerability and harms of individual statins: a study-level network meta-analysis of 246 955 participants from 135 randomized, controlled trials Circulation: Cardiovascular Quality and Outcomes, 6 (4). 390-399. ISSN 1941-7705

Mossialos, Elias and Naci, Huseyin and Courtin, Emilie (2013) Expanding the role of community pharmacists: policymaking in the absence of policy-relevant evidence? Health Policy, 111 (2). 135-148. ISSN 0168-8510

Naci, Huseyin and Brugts, Jasper Jan and Fleurence, Rachael and Ades, Anthony E. (2013) Dose-comparative effects of different statins on serum lipid levels: a network meta-analysis of 256,827 individuals in 181 randomized controlled trials European Journal of Preventive Cardiology, 20 (4). 658-670. ISSN 2047-4873

Naci, H. and Brugts, J. J. and Fleurence, R. and Tsoi, B. and Toor, H. and Ades, A. E. (2013) Comparative benefits of statins in the primary and secondary prevention of major coronary events and all-cause mortality: A network meta-analysis of placebo-controlled and active-comparator trials European Journal of Preventive Cardiology, 20 (4). 641-657. ISSN 2047-4873


Winter, H.S. and Mossialos, E. and Naci, Huseyin and Chandra, A. and Salojee, H. and Yamashiro, Y. and Bhutta, Z.A. and Uauy, R. and Corvalan, C. (2012) The economics of health care delivery Journal of Pediatric Gastroenterology and Nutrition, 55 (5). 482-488. ISSN 0277-2116

Naci, Huseyin and Cylus, Jonathan and Vandoros, Sotiris and Sato, Azusa and Perampaladas, Kumar (2012) Raising the bar for market authorisation of new drugs BMC, 345. e4261-e4261. ISSN 1756-1833

Naci, Huseyin and Cylus, Jonathan (2012) Why a stricter regulation of drugs could foster (not deter) pharmaceutical innovation British Politics and Policy at LSE (21 Sep 2012) Blog entry

Rahmioglu, Nilufer and Naci, Huseyin and Cylus, Jonathan (2012) Improving health care services in Northern Cyprus: a call for research and action European Journal of Public Health, 22 (6). 754-755. ISSN 1101-1262

Chisholm, Daniel and Naci, Huseyin and Hyder, Adnan Ali and Tran, Nhan T. and Peden, Margie (2012) Cost effectiveness of strategies to combat road traffic injuries in sub-Saharan Africa and South East Asia: mathematical modelling study BMC, 344 (mar02). e612-e612. ISSN 0959-8138

Naci, Huseyin and de Lissovoy, Gregory and Hollenbeak, Christopher and Custer, Brian and Hofmann, Axel and McClellan, William and Gitlin, Matthew (2012) Historical clinical and economic consequences of anemia management in patients with end-stage renal disease on dialysis using erythropoietin stimulating agents versus routine blood transfusions: a retrospective cost-effectiveness analysis Journal of Medical Economics, 15 (2). 293-304. ISSN 1369-6998

Sorenson, Corinna and Naci, Huseyin and Cylus, Jonathan and Mossialos, Elias (2011) Evidence of comparative efficacy should have a formal role in European drug approvals British Medical Journal, 343 (7822). d4849-d4849. ISSN 0959-8138

Naci, Huseyin and Fleurence, Rachael (2011) Using indirect evidence to determine the comparative effectiveness of prescription drugs: do benefits outweigh risks? Health Outcomes Research in Medicine, 2 (4). e241-e249. ISSN 1877-1319


Fleurence, Rachel L. and Naci, Huseyin and Jansen, Jeroen P. (2010) The critical role of observational evidence in comparative effectiveness research Health Affairs, 29 (10). 1826-1833. ISSN 0278-2715

Naci, Huseyin and Fleurence, Rachael and Birt, Julie and Duhig, Amy (2010) Economic burden of multiple sclerosis PharmacoEconomics, 28 (5). 363-379. ISSN 1170-7690

McIntyre, Roger S. and Cragin, Lael and Sorensen, Sonja and Naci, Huseyin and Baker, Tim and Roussy, Jean-Pascal (2010) Comparison of the metabolic and economic consequences of long-term treatment of schizophrenia using ziprasidone, olanzapine, quetiapine and risperidone in Canada: a cost-effectiveness analysis Journal of Evaluation in Clinical Practice, 16 (4). 744-755. ISSN 1356-1294

Naci, Huseyin and Fleurence, Rachael and Birt, Julie and Duhig, Amy (2010) The impact of increasing neurological disability of multiple sclerosis on health utilities: a systematic review of the literature Journal of Medical Economics, 13 (1). 78-89. ISSN 1369-6998


Naci, H. and Chisholm, D. and Baker, T. D. (2009) Distribution of road traffic deaths by road user group: a global comparison Injury Prevention, 15 (1). 55-59. ISSN 1353-8047


Chisholm, Dan and Naci, Huseyin (2008) Road traffic injury prevention: an assessment of risk exposure and intervention cost-effectiveness in different world regions HSF discussion papers, World Health Organization, Geneva, Switzerland.

Naci, Huseyin and Baker, Timothy D. (2008) Productivity losses from road traffic deaths in Turkey International Journal of Injury Control and Safety Promotion, 15 (1). 19-24. ISSN 1745-7300


Naci, Huseyin and Leontsini, Elli and Baker, Timothy D. (2007) One island, two parts, shared aspirations Harvard Health Policy Review, Fall (2). 108-110. ISSN 1533-774X

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Harvard University Thomas O. Pyle Fellowship in Population Medicine (2013-2014) Harvard Medical School Fellowship in Pharmaceutical Policy Research (2012-2013) Delta Omega, Alpha Chapter – United States National Honor Society for Public Health (2008) Cyprus Fulbright Commission – Cyprus-America Scholarship Program Full Recipient (2006-2008)

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