A full study of EU pharmaceutical trade concludes that there are no direct benefits to patients and recommends a re-evaluation of current practice by policymakers.
This 200 page study by Dr Panos Kanavos, lecturer in international health policy at LSE, amplifies and brings as up-to-date as possible research findings he presented in November 2003.
He challenges the accepted view that pharmaceutical parallel trade benefits healthcare stakeholders and patients through opening up medicine provision and lowering costs.
The study, which analyses the impact of cross-border brand-name prescription medicine trade within the European Union, suggests that although the overall number of parallel imports is continuing to increase, healthcare stakeholders are realizing few of the expected savings. Further, the study demonstrates that profits from parallel imports accrue mostly to the benefit of the third-party companies that buy and resell these medicines. Coming as most EU countries have introduced legislation to encourage the use of parallel-imported medicines, the study provides essential reading for all involved in the debate, from the consumer to Government.
The study's key objective was to provide a basis for assessing the relative future healthcare and industrial policy implications of parallel imports, with particular consideration for the fundamental principle of free movement of goods within the European Union. Parallel trade refers to the practice of importing brand-name pharmaceuticals from other EU countries, whose governments have set relatively low prices for innovative new medicines. Pharmaceutical parallel trade is thus the result of national price setting in the EU and the free movement of goods. A key driver behind the study was the lack of official data on pharmaceutical parallel imports or exports from the majority of EU countries, making informed debate on the pros and cons of the practice impossible.
Parallel trade of prescription medicines has to date been justified by several key and widely-supported economic hypotheses, summarised as follows by the LSE team:
Cross-country effect: Parallel trade leads to price equalisation across countries - 'arbitrage' leading to more efficient market operation
Destination country effect: Increased price competition in destination countries reduces overall pharmaceutical prices, benefiting payers and patients
Aggregate welfare effects: If price competition is the result of parallel trade, then the resulting price convergence may lead to overall welfare improvements for payers
Patient benefits: Patient access to innovative medicines is improved, with lower direct and indirect costs
Industry impact: Parallel trade has minimal impact on the pharmaceutical industry as a whole, in terms of profitability and potential to innovate, and indeed, improves overall industry efficiency
Top-line results of the LSE study, which was part-funded by Johnson & Johnson, has now provided concrete evidence to refute all of these hypotheses. The study demonstrated clearly that the vast majority of benefits from parallel trade accrue directly to parallel importers, where gross profits and revenues accrue over time in line with higher penetration rates. Taking the same sample of products across all study countries it is shown that parallel imports for 2002 sales to the six major destination countries accounted for only 0.3-2 per cent of national medicine budgets, representing a total saving of just €44.7 million (or €100 million if estimates for the clawback are included) over locally developed and manufactured products. In contrast, the parallel importers who bought these same medicines from across the EU, made profits of €648 million. In the UK, the NHS saved €55.9 million (if the clawback is included), or 2.8 per cent of the medicines budget from parallel imports in 2002, versus a mark-up of 49 per cent and profits of €469 million made by the parallel importers who sold these products
Dr Kanavos said: 'The study clearly makes the case for urgent further debate before any additional legislation in support of parallel trade is passed, at EU or country level. There is no evidence of sustainable dynamic price competition in destination countries, with no corresponding indirect cost savings. The supposed benefits of this system need to be reviewed.'
For more information contact Sandra Ma, LSE Press Office, 020 7955 7060.
The LSE research team used the IMS pharmaceutical sales database to track the sources, acquisition costs and sales of specific medicines in the European Union. Research focused on the sales of nineteen high volume medicines from six major drug classes over the period 1997-2002, including three widely-prescribed types of heart medicines - statins, ACE I and ACE II inhibitors; the newest and best selling categories of gastrointestinal and anti-depression treatments - proton pump and selective serotonin reuptake inhibitors respectively; and atypical anti-psychotic agents.
EU destination countries were considered as Denmark, Germany, the Netherlands, Norway, Sweden and the UK; EU source countries were considered as including all member states other than the destination country examined at the time.
US tops table of drug spending (9 June 05)
Article looks at the rise in spending on pharmaceuticals. Reference to LSE research on parallel importing, where drugs are moved across borders to take advantage of pricing differentials. The study showed recently that there is little or no impact on the amount of money countries pay for their drugs from parallel importing - instead, most of the benefit is to the importer itself.
European Union should liberalize drug market, EU judge says (18 April 05)
Reference to research by LSE in 2003 on parallel trade.
Updated 27 January 2004